Manic episodes. Bupropion can result in a lot of people who were manic or depressed in past times to be manic or frustrated yet again.Tend not to just take CONTRAVE In case you have uncontrolled large hypertension; have or have had seizures; use other medicines that have bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN